Psilocybin as a Treatment for Anorexia Nervosa

Before participants can take part in the study they will undergo three telephone screening calls (~1 hour each) and an in-person screening visit at Imperial College London (~5 hours). In the weeks before the first psilocybin dosing session participants will have multiple preparation calls with the study team. Participants must be available for in-person study visits on Wednesdays, Thursdays, and Fridays.

Study visit 1 (Wednesday ~7-8 hours): EEG brain recording, MRI brain recording, in-person preparation session, questionnaires
Study visit 2 (Thursday ~8 hours): First psilocybin dosing session, questionnaires
Study visit 3 (Friday ~4-5 hours): Integration session and EEG brain recording, questionnaires
Study visit 4 (Thursday ~8 hours): Second psilocybin dosing session, questionnaires (remote telephone preparation session one day before)
Study visit 5 (Friday ~4-5 hours): Integration session and EEG brain recording, questionnaires
Study visit 6 (Thursday ~ 8 hours): Third psilocybin dosing session, questionnaires (remote telephone preparation session one day before)
Study visit 7 (Friday ~4-5 hours): Integration session and EEG brain recording, questionnaires
Study visit 8 (Friday ~6-7 hours): Final follow-up session involving EEG brain recording, MRI brain recording, and final integration session, questionnaires

Participants will be expected to complete online surveys before, during and after the 6-week period of the study. There will also be surveys to complete monthly for 6 months after the follow-up visit, and then a final survey at 12 months. These surveys can take up to 1 hour to complete.

The cost of travel expenses will be covered. Overnight onsite accommodation around dosing days will be available. Participants will not be paid.